Genetic Mutation Involved in Natural and Herbal Dietary Supplements in Virginia and Maryland

Herbal Dietary Supplements

There are two variations, or forms, of mutations that may arise from the relatively common genetic mutation. The mutations may affect either (heterozygous) or both (homozygous) of the two MTHFR genes. Having a parent or close relative who has a MTHFR gene mutation may increase the persons risk of inheriting the same variant himself.

Although an MTHFR gene mutation may be identifiable by means of genetic testing, organizations like the American Heart Association (AHA) advise against screening for common MTHFR gene variants with regards to cardiovascular risk. The recommendation is made because a common gene mutation, by itself, without any other symptoms, is not considered to be an important risk factor for heart disease, and results from the test do not have much effect on health care management. There is some concern about whether some health problems are related to a mutation in the relatively common genetic disorders, and testing has been becoming more prevalent in recent years. A 2006 study found that 59% had several homozygous gene mutations, including the one for MTHFR, associated with blood clotting, while just 10% of women in a control group had it.

Potential for Supplementation A relatively common gene mutation disrupts how the body processes folate and other essential B vitamins. Changing supplementation of this nutrient is a potential target to address a relatively common genetic mutation.

Folate is a common form of folate found in many vitamins and supplements. Folates include the naturally occurring folates found in foods, such as leafy green vegetables, citrus fruits, and beans, as well as different types of folates found in dietary supplements, such as folic acid and methyltetrahydrofolate (5-MTHF). People with the MTHFR variant C677T are capable of processing all types of folate, including folic acid. Dietary Considerations Eating foods high in folate can help to support your levels of this essential vitamin naturally.

This multivitamin is not based on foods, and does not contain all the natural co-enzymes, co-factors, and bioflavonoids found in foods-based vitamins and minerals. This prenatal is also quite high in all vitamins and minerals, and also includes some useful foods and herbs.

You can even make your own prenatal vitamins according to your specific biological needs. If you really create your own, be sure to include folate, magnesium, iodine, zinc, iron, as well as vitamins A, D, C, K, and B.

According to the lab doors study, the Perfect Prenatal contains 99% less vitamin B6 than it says on the label, so an extra B supplement might be necessary. It also contains lots of iron, which can irritate some moms, and contains substantially less vitamin B6 than is stated on the label. Its prenatal mix is lower in vitamin A, but this should not be an issue if you are taking cod liver oil.

The acronym MTHFR is getting some attention because of the relatively common genetic mutation. Testing for MTHFR Mutations Various medical organizations including the American College of Obstetricians and Gynecologists, College of American Pathologists, American College of Medical Genetics, and American Heart Association do not recommend checking for the variants unless the individual also has very high homocysteine levels or other health indicators. Talk with your doctor or a genetic counselor if you have concerns about what having one of these exceedingly rare MTHFR gene variants means for your healthcare.

Conditions Related to Mutations in the MTHFR Gene Mutations in the MTHFR gene may impact your bodys ability to process amino acids namely, homocystein which may result in a number of negative health outcomes. Diseases known to be linked to polymorphisms in the MTHFR gene include neural tube defects, such as spina bifida, and homocystinuria elevated levels of the amino acid homeocysteine detected in urine. A complex mix of environmental and genetic factors causes neural tube defects, and in addition to the MTHFR SNP, several genetic mutations may contribute to homocystinuria. Genetic mutations are heritable, meaning that you get them from your parents.

Scientists have been expounding on the biology of aging ever since they discovered the one-gene mutations that doubled lifespans in worms, and they have identified the hallmarks of classical molecular ageing. Most aged individuals, whether they suffer from aging-related diseases like type-2 diabetes, cardiovascular diseases, and cancer, choose to use natural products or supplements to manage or quell any aging-related discomfort. This observation has been shown in laboratory studies to suggest that nutritional health supplements and natural products can reverse or delay aging-related physiological functional decline.

Genetic variants reflecting higher vitamin E status in men are associated with a decreased risk of prostate cancer. Supplemental selenium, with or without vitamin E, is associated with significant increased risk for advanced prostate cancer in individuals with higher than lower levels of selenium. In the Physicians Health Study II (PHS II), which followed 14,641 healthy men aged 50 years or older, supplementation with 400 IU of synthetic vitamin E (equivalent to 180 mg RRR-a-tocopherol) every other day for eight years had no effect on risk for prostate cancer, other site-specific cancers, or overall cancers. Few adverse effects were noted among adults who took less than 2000 mg of daily A-tocopherol supplements (either natural or synthetic vitamin E).

The forms of a-tocopherol that are consistent with recommended consumption are RRR-a-tocopherol the only naturally occurring form of vitamin E and the three synthetic isomers, RRS-, RSR-, and RSS-a-tocopherol, found in nutritional supplements and enriched foods. Dietary supplements are products not sold as regular foods, but are intended to complement or enhance diets containing one or more vitamins, minerals, amino acids, or botanicals (except tobacco). However, results from several large RCTs suggest that supplementing with vitamin E may influence prostate cancer risk. An index score of 3 could indicate a gene A mutation as well as gene B mutation, leading to an easy-to-understand, easy-to-understand, simple report for both clinicians and patients, providing insights on disease diagnosis, stratification, prognosis, as well as the metabolism, effectiveness, and/or toxicity associated with particular vitamins, minerals, herbal supplements, homeopathic ingredients, and other ingredients in the dietary and/or supplement regimen.